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Related Experiment Videos

Initial human experience with Permalens myopic hydrogel intracorneal lens implants.

T P Werblin1, A S Patel, J I Barraquer

  • 1University of Virginia, Charlottesville.

Refractive & Corneal Surgery
|January 1, 1992
PubMed
Summary

This study shows the first human use of Permalens hydrogel intracorneal lenses for myopia correction. While successful, undercorrection was noted, with plans for improved prediction and interchangeability for better refractive outcomes.

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Area of Science:

  • Ophthalmology
  • Biomedical Engineering

Background:

  • Nonhuman primate studies validated Permalens hydrogel intracorneal lenses for refractive error correction.
  • This marks the initial human application of these lenses for myopia.

Purpose of the Study:

  • To document the first human experience with myopic Permalens hydrogel intracorneal lens implants.
  • To evaluate the safety and efficacy of these lenses in human subjects.

Main Methods:

  • An 18-month follow-up was conducted on five patients receiving minus power hydrogel intracorneal lenses.
  • Preoperative spherical refraction averaged -14.00 +/- 5.00 diopters.

Main Results:

  • Refractive corrections up to 13.00 D were achieved.
  • A mean undercorrection of -5.00 +/- 2.10 D from predicted correction was observed.

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  • Rapid visual recovery was noted, with maximum acuity typically achieved within one month, and no significant complications.

    • Conclusions:

    • Myopic refractive changes were successfully achieved in all five human subjects.
    • Significant undercorrection remains a challenge, necessitating further research into lens power prediction.
    • The potential for surgical interchangeability of lenses offers a solution for residual refractive errors.