Related Experiment Video
Updated: Aug 20, 2026

Improved Preparation and Preservation of Hippocampal Mouse Slices for a Very Stable and Reproducible Recording of Long-term Potentiation
Published on: June 26, 2013
Memory consolidation and reconsolidation in the rat pup require protein synthesis
Nadège Gruest1, Paulette Richer, Bernard Hars
1Laboratoire de Neurobiologie de l'Apprentissage, de la Mémoire, et de la Communication, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 8620, Université Paris-sud, 91405 Orsay Cedex, France.
Abstract:
Little is known about the ontogenesis of memory, whether it appears with its full characteristics or whether they emerge progressively with development. In the adult, basic characteristics of memory processing are consolidation of memory after acquisition and reconsolidation after retrieval. Here, using a conditioned aversion paradigm and postlearning or postreactivation injection of a protein synthesis inhibitor, we show that memory acquired by rat pups as early as postnatal day 3 requires time-dependent protein synthesis after both learning and reactivation. These results present the first evidence suggesting that consolidation and reconsolidation are original properties of memory function.
Related Concept Videos
Ribosomal RNA Synthesis
Ribosome biogenesis begins with the synthesis of 5S and 45S pre-rRNAs by distinct RNA polymerases. The primary transcripts are extensively processed and modified before they are bound and folded by ribosomal proteins and assembly factors,...
Long-term Potentiation
Long-term Depression
Calcium Ion Concentration Mechanism
If over time, all...

