Related Experiment Video
Updated: Jul 9, 2026
08:31
Porous Silicon Microparticles for Delivery of siRNA Therapeutics
Published on: January 15, 2015
Nanoporous SiC: a candidate semi-permeable material for biomedical applications.
A J Rosenbloom1, D M Sipe, Y Shishkin
1Molecular Biosensors and Imaging Center, Carnegie Mellon University, Pittsburgh, PA 15213, USA. alan2@andrew.cmu.edu
Biomedical Microdevices
|November 19, 2004
Summary
Free-standing silicon carbide (SiC) nanoporous membranes allow protein diffusion up to 29000 Daltons and exhibit low protein adsorption, comparable to polymer membranes.
Area of Science:
- Materials Science
- Nanotechnology
- Biomaterials
Background:
- Nanoporous membranes are crucial for separation technologies.
- Silicon carbide (SiC) offers unique material properties for advanced applications.
Purpose of the Study:
- To fabricate and characterize free-standing silicon carbide (SiC) nanoporous membranes.
- To evaluate the protein diffusion and adsorption properties of these SiC membranes.
Main Methods:
- Fabrication of free-standing SiC nanoporous membranes in p-type and n-type materials.
- Protein diffusion studies using molecules up to 29000 Daltons.
- Radioactive labeling of albumin to assess protein adsorption.
Main Results:
- Successfully fabricated free-standing SiC nanoporous membranes.
- Demonstrated selective protein diffusion, permitting molecules up to 29000 Daltons while excluding larger ones.
- Achieved very low protein adsorption on porous SiC, comparable to commercial polymer membranes.
Conclusions:
- Free-standing SiC nanoporous membranes are effective for size-selective protein separation.
- SiC nanoporous membranes exhibit excellent low protein adsorption characteristics.
- These SiC membranes show potential as alternatives to polymer membranes in biomaterial applications.
