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Related Experiment Videos

The angiotensin IV/AT4 receptor.

S Y Chai1, R Fernando, G Peck

  • 1Neurochemistry, Howard Florey Institute, The University of Melbourne, Parkville, Victoria 3010, Australia. sychai@hfi.unimelb.edu.au.

Cellular and Molecular Life Sciences : CMLS
|November 19, 2004
PubMed
Summary
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Angiotensin IV (Ang IV) and LVV-hemorphin 7 enhance learning and memory by interacting with the AT(4) receptor, identified as insulin-regulated membrane aminopeptidase (IRAP). This interaction may involve IRAP inhibition or modulation of glucose transport.

Area of Science:

  • Neuroscience
  • Biochemistry
  • Physiology

Background:

  • The angiotensin AT(4) receptor was initially defined by angiotensin IV (Ang IV) binding.
  • LVV-hemorphin 7 is also a bioactive ligand for the AT(4) receptor.
  • Central administration of AT(4) receptor ligands enhances memory and reverses amnesia in rodents.

Purpose of the Study:

  • To investigate the role of the AT(4) receptor in memory formation.
  • To identify the molecular identity of the AT(4) receptor.
  • To explore potential mechanisms underlying the memory-enhancing effects of AT(4) receptor ligands.

Main Methods:

  • Characterization of AT(4) receptor binding and function.
  • Identification of the AT(4) receptor as insulin-regulated membrane aminopeptidase (IRAP).

Related Experiment Videos

  • Analysis of IRAP's cellular localization and enzymatic activity.

    • Main Results:

    • Ang IV and LVV-hemorphin 7 administration improves learning and memory in rodent models.
    • The AT(4) receptor is identified as IRAP, a type II integral membrane enzyme.
    • IRAP is found in GLUT4 vesicles and exhibits aminopeptidase activity.

    Conclusions:

    • The AT(4) receptor/IRAP system plays a significant role in memory processes.
    • Ligands like Ang IV may enhance memory by inhibiting IRAP or modulating glucose transport via GLUT4.
    • IRAP may function as a receptor, signaling through its intracellular domain.