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Significant weight loss after laparoscopic Nissen fundoplication.

C Neumayer¹, R Ciovica, M Gadenstätter

¹Department of General Surgery, Hospital Krems, Mitterweg 10, 3500, Krems, Austria.

Surgical Endoscopy

|November 19, 2004

Summary

Laparoscopic Nissen fundoplication (LNF) significantly reduces body weight in GERD patients. This weight loss is persistent and more pronounced in women and obese individuals.

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Area of Science:

Gastroenterology
Bariatric Surgery
Surgical Innovation

Background:

Laparoscopic Nissen fundoplication (LNF) is a standard surgical treatment for gastroesophageal reflux disease (GERD).
The relationship between body weight and GERD, and the impact of LNF on weight, remain under-investigated.
This study explores the effects of LNF on body weight and quality of life in GERD patients.

Purpose of the Study:

To investigate the impact of Laparoscopic Nissen fundoplication (LNF) on body weight in patients with gastroesophageal reflux disease (GERD).
To assess changes in body mass index (BMI) and overall quality of life following LNF.
To identify patient characteristics associated with weight changes after LNF.

Main Methods:

A cohort of 213 GERD patients underwent LNF between July 2000 and March 2003.

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Preoperative assessments included clinical evaluation, endoscopy, barium swallow, 24-h pH-metry, and manometry.

Follow-up evaluations for body weight and quality of life were conducted at 3 and 12 months post-surgery.

Main Results:

Mean BMI significantly decreased from 27.6 to 26.0 kg/m² post-LNF (p < 0.001), with an average weight loss of 3.9 kg.
Weight reduction was more significant in women and obese patients compared to men and lean patients.
Gastrointestinal Quality of Life Index and GERD-Health Related Quality of Life Index scores showed marked improvement post-LNF.

Conclusions:

Laparoscopic Nissen fundoplication results in significant and sustained body weight loss in GERD patients.
The procedure also leads to substantial improvements in patients' quality of life.
Weight loss following LNF is independent of dysphagia and does not affect plasma lipid levels.