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Steroids from the roots of Cynanchum stauntonii
Peng Wang1, Hai-Lin Qin, Ling Zhang
1Institute of Materia Medica, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing , P.R. China.
Abstract:
A chemical investigation of the roots of Cynanchum stauntonii has resulted in the characterization of a new hydroperoxide with a 13,14 : 14,15-disecopregnane-type skeleton, named stauntonine (1), together with three related compounds, anhydrohirundigenin (2), anhydrohirundigenin monothevetoside (3), and glaucogenin-C mono- D-thevetoside (4). Their structures were established by spectroscopic methods, including X-ray crystallographic diffraction analysis of stauntonine that confirmed its relative stereochemistry. The compound 1 showed dose-dependent relaxation on aortic rings with endothelium contracted by phenylepherine or KCl.
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