Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

An incidence density sampling program for nested case-control analyses.

D B Richardson1

  • 1Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, NC 27599-8050, USA. david_richardson@unc.edu

Occupational and Environmental Medicine
|November 20, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cancer among workers.

Annals of the ICRP·2026
Same author

Using negative controls to identify causal effects with invalid instrumental variables.

Biometrika·2025
Same author

Lifetime excess absolute risk for lung cancer due to exposure to radon: results of the pooled uranium miners cohort study PUMA.

Radiation and environmental biophysics·2024
Same author

Mortality among uranium miners in North America and Europe: the Pooled Uranium Miners Analysis (PUMA).

International journal of epidemiology·2020
Same author

Dose Estimation for a Study of Nuclear Workers in France, the United Kingdom and the United States of America: Methods for the International Nuclear Workers Study (INWORKS).

Radiation research·2015
Same author

The effects of building-related factors on classroom relative humidity among North Carolina schools participating in the 'Free to Breathe, Free to Teach' study.

Indoor air·2014
Same journal

Mortality among Fukushima nuclear emergency workers, 2012-2021.

Occupational and environmental medicine·2026
Same journal

Economic burden of musculoskeletal pain in Danish senior workers: a working-life expectancy approach.

Occupational and environmental medicine·2026
Same journal

Parental occupational exposure to pesticides at birth and risk of adult testicular germ cell tumours in offspring: a French nationwide case-control study.

Occupational and environmental medicine·2026
Same journal

Occupational standing, walking and forward bending during pregnancy and the risk of miscarriage: a Danish nationwide, register-based, cohort study.

Occupational and environmental medicine·2026
Same journal

Quantitative silica dust exposure and lung cancer incidence in hard rock miners: 1.6 million person-years of follow-up in the Mining Master File cohort study.

Occupational and environmental medicine·2026
Same journal

Using social media to highlight inhaled occupational exposures as a cause of lung disease.

Occupational and environmental medicine·2026
See all related articles

This study introduces a new computer program for incidence density sampling in nested case-control studies. The program provides unbiased relative risk estimates, overcoming bias found in previous methods.

Area of Science:

  • Epidemiology
  • Biostatistics

Background:

  • Nested case-control studies offer efficient epidemiological investigation.
  • Accurate relative risk estimation requires incidence density sampling for control selection.

Purpose of the Study:

  • To present a simple computer program for incidence density sampling.
  • To evaluate the program's performance in obtaining unbiased relative risk estimates.

Main Methods:

  • Developed and evaluated a computer program for incidence density sampling.
  • Used data from a cohort mortality study in the nuclear weapons industry.
  • Compared results with a previously proposed sampling program and proportional hazards regression.

Main Results:

  • The new incidence density sampling program yielded unbiased relative risk estimates.

Related Experiment Videos

  • A previously proposed program by Pearce (1989) produced biased estimates, with bias increasing with more controls.
  • Conditional logistic regression was used for exposure-mortality association estimation.

    • Conclusions:

    • The described computer program provides a simple, unbiased method for incidence density sampling in nested case-control studies.
    • This approach ensures exact matching on attained age and proper enumeration of eligible controls.
    • It effectively addresses bias issues associated with earlier incidence density sampling programs.