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[Effects of osthol on androgen level and nitric oxide synthase activity in castrate rats]
Juanli Yuan1, Jinxian Xie, Aiyuan Li
1Guangxi College of TCM, Nanning 530001.
Objective:
To investigate the effects of osthol on androgen level and nitric oxide synthase (NOS) activity in castrate rats.
Methods:
Immature castrate male rats were treated with osthol daily for 20 d. The levels of testosterone(T), luteinizing hormone (LH) and follicle stimulating hormone (FSH) in serum and the activity of NOS, the nitric monoxide (NO) level in penis tissue were determined.
Results:
T( P < 0.05), LH( P < 0.05) and FSH( P < 0.01) were significantly increased at the high dose of osthol treatment. The high and low dose of osthol treatment significantly enhanced the activity of NOS (P < 0.01).
Conclusion:
Osthol could increase androgen, gonadotropin and nitric oxide synthase (NOS) activity. It suggested that osthol had androgen-like effect and gonadotropin-like effect.
