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Fertility rates with delayed fibrin glue: vasovasostomy in rats
1Department of Urology, Long Island Jewish Medical Center, New Hyde Park, New York.
Objective:
To determine if fibrin glued vasovasostomy had comparable fertility rates to sutured vasovasostomy.
Design:
Twenty adult male Sprague-Dawley rats underwent bilateral vasectomy. Two weeks after vasectomy, 10 rats had a bilateral sutured vasal anastomosis consisting of four mucosal and four seromuscular sutures with 10-0 nylon. The second group of 10 rats underwent bilateral fibrin glue vasal anastomosis consisting of two transmural sutures with 10-0 nylon followed by application of fibrin glue. One month after vasectomy reversal, each male rat was mated with a female rat for a period of 2 weeks.
Setting:
Animal laboratory. PATIENTS PARTICIPANTS: Twenty male Sprague-Dawley rats.
Interventions:
Bilateral vasectomies in 20 male Sprague-Dawley rats. Two weeks after vasectomy, 10 rats had bilateral sutured vasal anastomosis, and 10 rats had bilateral glued vasal anastomosis.
Main Outcome Measures:
Pregnancy after vasectomy reversal.
Results:
Ten of 10 rats in the sutured group produced offspring for a fertility rate of 100%. Eight of 10 rats in the fibrin glue group produced offspring for a fertility rate of 80%. There was no statistically significant difference in the pregnancy rates between the two groups at the 95% confidence interval.
Conclusion:
Fibrin glue-delayed vasectomy reversal produces comparable fertility rates compared with conventional sutured vasectomy reversal in the rat.