Pathology of mesothelioma

In this article, progress in distinguishing mesothelioma from mesothelial hyperplasia and fibrosing pleuritis was discussed. Advances in the immunohistochemical characterization of mesothelioma, in the recognition of entities that mimic mesothelioma, and in their distinction from mesothelioma were reviewed. Cytogenetic and molecular genetic contributions to the diagnosis of pleural synovial sarcoma were briefly summarized. The diagnosis of epithelial type mesothelioma can be established in most cases. Several mesotheliomas, however, especially rare subtypes, and sarcomatoid, desmoplastic, and poorly differentiated mesotheliomas continue to present diagnostic challenges.