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[Incidence of acute pancreatitis in children with inflammatory bowel disease]

Andrzej Stawarski1, Franciszek Iwańczak

  • 1II Katedra i Klinika Pediatrii, Gastroenterologi i Zywienia AM we Wrocławiu.

Polski Merkuriusz Lekarski : Organ Polskiego Towarzystwa Lekarskiego
|November 24, 2004
PubMed

Insights

Pediatric inflammatory bowel disease (IBD) patients, particularly those with moderate to severe ulcerative colitis (UC), have a notable risk of acute pancreatitis. Increased pancreatic enzymes were also frequently observed in children with Crohn's disease (CD) and UC.

Area of Science:

  • Pediatric Gastroenterology
  • Hepatology
  • Internal Medicine

Context:

  • Inflammatory bowel disease (IBD) encompasses chronic conditions like ulcerative colitis (UC) and Crohn's disease (CD).
  • Children with IBD may face various complications, including pancreatic issues.
  • Previous research on pancreatic involvement in pediatric IBD is limited.

Purpose:

  • To determine the incidence of acute pancreatitis in children diagnosed with IBD.
  • To assess the frequency of elevated pancreatic enzyme activity in the serum of pediatric IBD patients.
  • To explore potential correlations between acute pancreatitis and disease severity or medication in this population.

Summary:

  • A study analyzed 101 children (3-18 years) with IBD (79 UC, 22 CD) over a 5-year period.
  • Acute pancreatitis occurred in 4.5% of pediatric CD patients and 5.1% of pediatric UC patients, more frequently in moderate to severe UC.
  • Elevated pancreatic enzymes (hyperamylasemia, hyperlipasemia, elevated urinary amylase) were observed in both CD and UC groups, with no medication correlation.

Impact:

  • This study highlights the significant risk of acute pancreatitis in children with IBD, especially UC.
  • Findings suggest routine monitoring for pancreatic complications in pediatric IBD patients may be warranted.
  • The data contributes to a better understanding of the extraintestinal manifestations of IBD in children.

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