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Selective Forms of Therapy in the Treatment of Inflammatory Bowel Diseases

Anna Kofla-Dłubacz1, Katarzyna Akutko1, Elżbieta Krzesiek1

  • 12nd Department of Paediatrics, Gastroenterology and Nutrition, Faculty of Medicine, Wroclaw Medical University, M. Sklodowskiej-Curie Str. 50/52, 50-367 Wroclawl, Poland.

Journal of Clinical Medicine
|February 25, 2022
PubMed

Selective interference with the functioning of the immune system consisting of the selective blockade of pro-inflammatory factors is a modern, promising, and developing strategy for the treatment of diseases resulting from dysregulation of the immune system, including inflammatory bowel disease. Inhibition of the TNF alpha pathway, group 12/23 cytokines, and lymphocyte migration is used in the treatment of severe or moderate ulcerative colitis and Crohn's disease. Intracellular signal transduction by influencing the phosphorylation of SAT (signal transducer and activator of transcription) proteins remains in clinical trials.

Keywords:
IBDlymphocyte migrationpro-inflammatory cytokinestreatment

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