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Determination of lipoic acid in dietary supplement preparations by capillary electrophoresis
Alberto Sitton1, Martin G Schmid, Gerald Gübitz
1Institute of Pharmaceutical Chemistry and Pharmaceutical Technology, Karl-Franzens University, Univ. Pl.1, Graz 8010, Austria.
Abstract:
The present study deals with the development of a method for the quantitative determination of lipoic acid in a dietary supplement preparation. A rapid capillary electrophoretic method is developed using UV detection at 208 nm. Although lipoic acid is only weakly UV-absorbing, at this wavelength it could be detected with sufficient sensitivity with an LOD and LOQ of 0.8 and 2.5 microg/ml, respectively. Analysis time was less than 9 min. The compound was extracted from tablets with a recovery of 98.3% and a precision of 2.8% RSD.
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