Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Mucosal immunity and tolerance in the elderly.

Kohtaro Fujihashi1, Jerry R McGhee

  • 1Immunobiology Vaccine Center, Departments of Oral Biology and Microbiology, The University of Alabama at Birmingham, 845 19th Street South, Bevill Biomedical Res. Bldg. Rm. 761, Birmingham, AL 35294, USA. kohtarof@uab.edu

Mechanisms of Ageing and Development
|November 27, 2004
PubMed
Summary

Aging impairs gastrointestinal (GI) immune responses, including secretory (S)-IgA and oral tolerance. Reduced Peyer

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cationic nanogel-based nasal therapeutic HPV vaccine prevents the development of cervical cancer.

Science translational medicine·2025
Same author

MucoRice-CTB line 19A, a new marker-free transgenic rice-based cholera vaccine produced in an LED-based hydroponic system.

Frontiers in plant science·2024
Same author

Mucosal vaccination: onward and upward.

Expert review of vaccines·2023
Same author

Cationic-nanogel nasal vaccine containing the ectodomain of RSV-small hydrophobic protein induces protective immunity in rodents.

NPJ vaccines·2023
Same author

Biodistribution assessment of cationic pullulan nanogel, a nasal vaccine delivery system, in mice and non-human primates.

Vaccine·2023
Same author

Human salivary protein-derived peptides specific-salivary SIgA antibodies enhanced by nasal double DNA adjuvant in mice play an essential role in preventing Porphyromonas gingivalis colonization: an in-vitro study.

BMC oral health·2023

Area of Science:

  • Immunology
  • Gastroenterology
  • Aging Research

Background:

  • Age-associated decline in gastrointestinal (GI) immune function, specifically secretory (S)-IgA immunity and oral tolerance, is well-documented.
  • Immune responses mediated by the gut-associated lymphoreticular tissue (GALT) are more vulnerable to aging than peripheral immune responses.
  • Impaired oral tolerance in aging may compromise GI homeostasis, as evidenced by young adult mice's failure to establish unresponsiveness to oral antigens.

Purpose of the Study:

  • To elucidate the precise mechanisms underlying the age-associated impairment of GI tract immune responses.
  • To investigate the role of mucosal inductive tissue dysfunction in age-related GI immune dysregulation.

Main Methods:

  • Analysis of Peyer's patch size in aged versus young mice.

Related Experiment Videos

  • Quantification of naive CD4+ T cells and dendritic cells (DCs) within Peyer's patches.
  • Assessment of essential cytokine synthesis required for immune induction.

    • Main Results:

    • A reduction in Peyer's patch size was observed in aged mice.
    • Frequencies of naive CD4+ T cells and dendritic cells (DCs) were decreased in the Peyer's patches of aged mice.
    • This reduction in cellular components led to insufficient cytokine synthesis for inducing S-IgA immunity and oral tolerance.

    Conclusions:

    • Age-associated dysregulation of GI immunity is linked to the dysfunction of mucosal inductive tissues, particularly Peyer's patches.
    • Reduced naive T cells and DCs in aged Peyer's patches impair the necessary cytokine environment for effective S-IgA and oral tolerance induction.
    • These findings highlight a cellular basis for immune decline in the aging gut, impacting mucosal homeostasis.