Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Chromatin modifiers and carcinogenesis.

Richard I Gregory1, Ramin Shiekhattar

  • 1Gene Expression and Regulation Program, and Molecular and Cellular Oncogenesis Program, Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA.

Trends in Cell Biology
|November 27, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Acidic bile salts induce APE1-dependent PRDX2 activation to drive oxaliplatin resistance via ferroptosis inhibition.

Redox biology·2026
Same author

The MLLT3 YEATS domain binds histone marks (H3K9/18/27ac/cr) and ncRNA (7SK), linking transcription and RNA signaling to regulate hematopoiesis.

Cell reports·2026
Same author

Emergence of protein-coding enhancer RNAs in primate evolution.

Trends in genetics : TIG·2026
Same author

Transcriptional competence defines the heterochromatin nucleating potential of isolated MSR units.

Nature communications·2026
Same author

Targeting tRNA-Arg-TCT-4-1 suppresses cancer cell growth and tumorigenesis.

bioRxiv : the preprint server for biology·2026
Same author

Unbalanced chromatin binding of Polycomb complexes drives neurodevelopmental disorders.

Molecular cell·2026
Same journal

Horizontal transfer of mitochondria in cancer: The physiology reborn in disease?

Trends in cell biology·2026
Same journal

Spindle errors: A stress test for epithelial robustness.

Trends in cell biology·2026
Same journal

Multicellular ecosystems: Linking cellular diversity to tissue function and disease.

Trends in cell biology·2026
Same journal

Orchestrating the signaling-bias at the protease-activated receptor, PAR1.

Trends in cell biology·2026
Same journal

Crashing by design: Utilizing DNA damage for MCC differentiation.

Trends in cell biology·2026
Same journal

The value of a shared lab: Our insights.

Trends in cell biology·2026
See all related articles

Chromatin organization controls gene access, and its disruption by modifiers is linked to cancer. Understanding these mechanisms aids in comprehending cellular transformation and oncogene function.

Area of Science:

  • Molecular Biology
  • Genetics
  • Cancer Biology

Background:

  • Chromatin, a dynamic nucleoprotein complex, regulates gene regulatory factor access to the eukaryotic genome.
  • Its organization is tightly controlled by ATP-dependent chromatin-remodeling complexes, histone-modifying enzymes, and specialized histone variants.
  • Perturbations in these chromatin modifiers are increasingly implicated in cancer development.

Purpose of the Study:

  • To elucidate the mechanisms by which chromatin influences cancer development.
  • To enhance understanding of chromatin organization regulation.
  • To explore the connections between tumor suppressor and oncogene function in the context of chromatin.

Main Methods:

  • Analysis of chromatin organization dynamics.

Related Experiment Videos

  • Investigation of ATP-dependent chromatin-remodeling complexes.
  • Study of histone-modifying enzymes and histone variants.
  • Examination of cellular transformation processes.
  • Research into tumor suppressor and oncogene interactions.

    • Main Results:

    • Recent findings highlight specific mechanisms linking chromatin regulation to cancer initiation and progression.
    • The study illustrates how chromatin configuration impacts cellular transformation.
    • Connections between the function of tumor suppressors and oncogenes are clarified through chromatin dynamics.

    Conclusions:

    • Chromatin organization plays a critical role in regulating nuclear processes and is intrinsically linked to cancer.
    • Understanding chromatin modifier functions is crucial for deciphering cancer development.
    • This research provides insights into the regulation of chromatin and its implications for oncogenesis.