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Related Experiment Videos

A new microencapsulation method using an ultrasonic atomizer based on interfacial solvent exchange.

Yoon Yeo1, Kinam Park

  • 1Department of Pharmaceutics, Purdue University, West Lafayette, IN 47907, USA.

Journal of Controlled Release : Official Journal of the Controlled Release Society
|November 30, 2004
PubMed
Summary
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A novel coaxial ultrasonic atomizer efficiently produces reservoir-type microcapsules. This method preserves lysozyme

Area of Science:

  • Materials Science
  • Chemical Engineering
  • Biotechnology

Background:

  • Microencapsulation is crucial for drug delivery and controlled release.
  • Traditional methods can be harsh, affecting encapsulated substance integrity.
  • Reservoir-type microcapsules offer advantages for sustained release applications.

Purpose of the Study:

  • To develop a mild and efficient method for producing reservoir-type microcapsules.
  • To elucidate the microencapsulation mechanism using a coaxial ultrasonic atomizer.
  • To evaluate the encapsulation and release characteristics of lysozyme.

Main Methods:

  • Utilized a coaxial ultrasonic atomizer for microcapsule fabrication.
  • Operated the atomizer in various modes to study the mechanism.

Related Experiment Videos

  • Investigated the effect of liquid flow rate ratios on encapsulation.
  • Encapsulated lysozyme and analyzed its release kinetics.

    • Main Results:

    • Reservoir-type microcapsules formed via midair collision of microdrops.
    • Encapsulation efficiency and microdrop distribution depended on flow rate ratios.
    • Lysozyme was encapsulated without loss of functional integrity.
    • Near zero-order release of lysozyme observed for over 50 days.

    Conclusions:

    • Coaxial ultrasonic atomization is a mild and effective technique for reservoir-type microcapsule production.
    • The midair collision mechanism offers control over encapsulation parameters.
    • This method is suitable for sensitive biomolecules like lysozyme, enabling long-term sustained release.