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Isolation, Behavioral Identification, and Pathogenicity Assessment of Entomopathogenic Fungi from a Forest Wood Borer
Published on: September 29, 2023
10-membered macrolides from the insect pathogenic fungus Cordyceps militaris BCC 2816
Vatcharin Rukachaisirikul1, Songyos Pramjit, Chaveng Pakawatchai
1Department of Chemistry, Faculty of Science, Prince of Songkla University, Songkhla 90112, Thailand. vatcharin.r@psu.ac.th
Abstract:
Three new 10-membered macrolides (1-3) have been isolated from the entomopathogenic fungus Cordyceps militaris BCC 2816, together with six known compounds, cepharosporolides C (4), E (5), and F (6), 2-carboxymethyl-4-(3'-hydroxybutyl)furan (7), cordycepin (8), and pyridine-2,6-dicarboxylic acid. The structures were determined by analysis of NMR data, and an X-ray analysis was performed to confirm the structure of 1. The antimalarial activity of 1-4 and 8 against Plasmodium falciparum K1 was evaluated.
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