HIV infection in two brothers receiving intravenous therapy for hemophilia

In January 1992, a state health department notified CDC about a 4-year-old boy with hemophilia who had become infected with human immunodeficiency virus (HIV). The virus was genetically similar to that of his 8-year-old brother, who had been previously infected with HIV through receipt of unscreened blood products for his hemophilia. This report summarizes the epidemiologic and laboratory findings of the investigation, which strongly suggest that the younger child became infected following exposure to needles or syringes used to provide intravenous therapy and that had been contaminated with his brother's blood.