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Published on: June 3, 2020
[Differences in cerebral glucose metabolism between frontotemporal lobar degeneration and Alzheimer's disease]
Stefan Poljansky1, Bernd Ibach, Matthias Vogel
1Klinik und Poliklinik für Psychiatrie und Psychotherapie der Universität Regensburg am Bezirksklinikum. stefan.poljansky@medbo.de
Objective:
To describe differences in cerebral glucose metabolism between frontotemporal lobar degeneration (FTLD) and Alzheimer's disease (AD).
Methods:
14 patients with FTLD (7 f/7 m, mean age 60.1 years) and 14 patients with AD (7 f/7 m, mean age 59.5 years) were examined. [18F]FDG positron emission tomography (PET) scans were analysed with statistical nonparametric mapping (SnPM) and statistical parametric mapping (SPM99).
Results:
Significant decreases in glucose metabolism in FTLD compared to AD were detected in the left insula/left inferior frontal gyrus (Brodman area [BA]13, 45 and 47) and in the medial frontal gyrus bilaterally (BA10). A significant decrease in AD compared to FTLD was identified in the right middle temporal gyrus (BA39).
Conclusion:
Cerebral PET could be a promising tool to discriminate FTLD from AD.
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