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Published on: June 8, 2021
[Incidence of rigor during treatment with flupentixol decanoate in comparison to risperidone]
Josef Scherer1, Peter Dobmeier, Karin Kuhn
1Klinik des Bezirks Oberbayern am Klinikum Garmisch-Partenkirchen. josef.scherer@psychiatrie-gap.de
Study Objective:
We investigated as to whether dosedependent extrapyramidal tolerance of Flupentixol decanoate is inferior to that of Risperidone.
Method:
143 Risperidone and 177 Flupentixol decanoate treated patients were consecutively entered into this non - randomized open study and assessed with the Simpson-Angus-Scale regarding presence of rigor. Treatment comparisons of rigor frequency was done by Kaplan-Meier analysis.
Results:
The risk of rigor increased with dose on both treatments. EPMS-risk was not increased under treatment with Flupentixol decanoate (mean dose 35.06 +/- 19.7 mg/2 weeks) compared to Risperidone (mean daily dose: 5.2 +/- 2.5 mg/kg) when comparable weight standardized Haloperidol equivalence doses (WHE) were used.
Conclusion:
This study offers limited evidence for methodological reasons. Yet, results do not support the view that EPS are more frequent on Flupentixol decanoate than on Risperidone when doses are comparable.
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