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Biological tissue adhesive for mesh-application in pigs: an experimental study
S Schulze1, V B Kristiansen, B Fischer Hansen
1Department of Surgery D, Glostrup University Hospital, Ndr. Ringvej, DK 2600 Glostrup, Denmark. svsc@glostruphosp.kbhamt.dk
Surgical Endoscopy
|December 2, 2004
Summary
This study evaluated a new laparoscopic mesh fixation technique using glue for inguinal hernia repair in pigs. Results showed no mesh migration or inflammation, suggesting potential for reduced complications in humans.
Area of Science:
- Minimally Invasive Surgery
- Surgical Materials Science
Background:
- Herniotomy can lead to postoperative complications like chronic pain, bleeding, and infection.
- Developing simpler, safer surgical procedures is crucial for patient outcomes.
Purpose of the Study:
- To evaluate a novel, simple operative procedure for intraperitoneal mesh application with glue.
- To assess the feasibility and safety of this technique in an experimental model before human trials.
Main Methods:
- Laparoscopic mesh insertion was performed in three pigs.
- Meshes were secured using a collagen-based glue.
- Pigs were observed for 8 weeks, followed by macroscopic and microscopic evaluation.
Main Results:
- Intraperitoneal meshes remained stable without migration during the 8-week study period.
- No signs of inflammation were observed in the surrounding tissues.
- Absence of adhesions around the implanted meshes was noted.
Conclusions:
- This technique shows promise for reducing complications in human inguinal herniotomy, including pain, seroma, and infection.
- The described operative technique is straightforward and potentially simplifies the procedure.
- Further research may validate this method for clinical application in hernia repair.