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[Study on association between aldosterone synthase gene polymorphism and the left ventricular structure and function
1Department of Cardiology, West China Hospital, Sichuan University, Chengdu, 610041, China.
Objective:
To investigate the association between a -344 C/T polymorphism of aldosterone synthase gene (CYP11B2) and the left ventricular structure and function of patients with dilated cardiomyopathy (DCM) in China.
Methods:
Eighty-nine patients with DCM were genotyped by PCR-RFLP, and were divided into TT, TC, CC and TT+CC four groups by their genotypes, respectively. Left ventricular structure and function were assessed with echocardiography.
Results:
There was no significant difference between four groups in left ventricular diameters, mass and ejection fraction in patients with DCM.
Conclusion:
The data were not in favor of a significant association between the aldosterone synthase gene CYP11B2 and the left ventricular structure and function in patients with DCM.
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