[Expression of estrogen and progesterone receptors and HER-2 by breast cancer cells]

Breast cell carcinomas removed from 62 women aged from 33 to 74 years were studied immunohistochemically. 24 tumours were of T1N0M0, 5-T1N1M0, 20-T2N0M0, 11-T2N1M0 and 2-T2N0M0. Invasive ductal carcinoma occurred in 59.6%, invasive ductal in 40.4%. Estrogen receptor expression was found in 59.6%, progesterone in 38.7%. Simultaneous expression of these receptors was in 35.5%. Estrogen receptor and progesterone receptor expression were registered in 24.2 and 3.2% cases, respectively. There was neither estrogen nor progesterone expression in 37%. HER-2 expression was observed in 45.2%, the highest being at the age from 50 to 55 years and in invasive ductal carcinoma. Enhancement of estrogen receptor expression was accompanied with lower rate of HER-2 expression. All three antigens expression does not depend on the presence or absence of metastases to the regional lymph nodes.