Related Experiment Video
Updated: Aug 20, 2026

Single-Molecule Fluorescence Visualization of DNA Polymerase Dynamics at G-Quadruplexes
Published on: April 4, 2025
Expanding the Hoogsteen edge of 2'-deoxyguanosine: consequences for G-quadruplex formation
Vladimir Gubala1, José E Betancourt, José M Rivera
1Department of Chemistry, University of Puerto Rico, Río Piedras Campus, Río Piedras, Puerto Rico 00931.
Abstract:
[structure: see text] The synthesis and self-assembling properties of 8-aryl-2'-deoxyguanosine derivatives are described. Our studies suggest that a properly placed acetyl group can increase the stability and specificity of the resulting G-quadruplex supramolecules by enhancing noncovalent interactions such as hydrogen bonds and pi-stacking.
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