Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

The mammalian cell cycle: an overview.

Jane V Harper¹, Gavin Brooks

¹School of Animal and Microbial Sciences, University of Reading, Reading, UK.

Methods in Molecular Biology (Clifton, N.J.)

|December 4, 2004

Summary

Mammalian cell cycle regulation involves precise protein activity control. This review details cell cycle phases and key regulatory molecules ensuring normal cellular progression.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Nox2 contributes to age-related oxidative damage to neurons and the cerebral vasculature.

The Journal of clinical investigation·2019

Same author

Transthoracic Echocardiographic Examination in the Rabbit Model.

Journal of visualized experiments : JoVE·2019

Same author

Percutaneous Contrast Echocardiography-guided Intramyocardial Injection and Cell Delivery in a Large Preclinical Model.

Journal of visualized experiments : JoVE·2018

Same author

Deoxyribonuclease 1 reduces pathogenic effects of cigarette smoke exposure in the lung.

Scientific reports·2017

Same author

Aging-associated metabolic disorder induces Nox2 activation and oxidative damage of endothelial function.

Free radical biology & medicine·2017

Same author

p22phox C242T Single-Nucleotide Polymorphism Inhibits Inflammatory Oxidative Damage to Endothelial Cells and Vessels.

Circulation·2016

Area of Science:

Molecular Biology
Cell Biology
Genetics

Background:

Cellular proliferation is fundamental to mammalian development and tissue homeostasis.
The cell cycle is a highly regulated sequence of events leading to cell division.
Dysregulation of the cell cycle is implicated in diseases like cancer.

Purpose of the Study:

To provide a comprehensive overview of the mammalian cell cycle.
To elucidate the regulatory mechanisms governing each phase of the cell cycle.
To highlight the critical roles of cell cycle regulatory molecules.

Main Methods:

Literature review of recent advances in cell cycle research.
Analysis of key proteins and their functions in cell cycle control.
Description of the distinct phases of the mammalian cell cycle.

Main Results:

Detailed description of G1, S, G2, and M phases.
Identification of cyclins, cyclin-dependent kinases (CDKs), and CDK inhibitors as key regulators.
Explanation of checkpoints that ensure accurate DNA replication and chromosome segregation.

Conclusions:

The mammalian cell cycle is a complex, tightly regulated process.
Specific regulatory molecules ensure orderly progression through cell division.
Understanding cell cycle regulation is crucial for addressing diseases associated with proliferation defects.

Related Experiment Videos