Related Experiment Video
Updated: Aug 20, 2026

Multimodal Approach to Assess Bone Regeneration and Scaffold Performance
Published on: February 13, 2026
[Bone quality in the respect of bone matrix]
1Division of Oral Anatomy, Department of Oral Biologycal Sience, Niigata University, Graduate School of Medical and Dental Science.
Abstract:
Bone is abundant in extracellular matrices, and therefore,"bone quality" appears to reflect the property of the bone matrix. The bone matrix is composed of minerals and organic materials. The volume of collagen fiber is approximately 90% of the whole organic materials of the bone matrix. Since collagen fibers could resist tension, the elasticity of the bone seems to come from the property of the collagen fibers. The mineralization of the bone matrix is achieved by the formation of hydroxyapatite crystals. The non-collagenous proteins and proteoglycans may regulate the growth of the mineralized crystal.
Related Concept Videos
The Bone Matrix
Bone as Supporting Connective Tissue
Bone Matrix
Bone, or osseous tissue, is a connective tissue that has a large amount of two different types of matrix material. The organic matrix is similar to the matrix material found in other connective tissues, including some amount of collagen and elastic fibers. This gives strength and flexibility to the tissue. The inorganic matrix consists of mineral salts— mostly calcium salts— that give the...
Bone Remodeling
Compact Bone
Compact bone, also called cortical bone, is the denser, stronger of the two types of bone tissue. It is found under the periosteum and in the diaphyses of long bones, where it provides support and protection. The microscopic structural unit of compact bone is called an osteon, or haversian system. Each osteon is composed of concentric rings of calcified...
Spongy Bone
Spongy bone is more porous, and less dense compared to compact bone. It is composed of concentric lamellae that are arranged irregularly to form the trabecular network. In some bones, the spaces between trabeculae contain red marrow, where...
Bone Disorders
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...

