Related Experiment Video
Updated: Aug 20, 2026

5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat
Published on: July 3, 2013
[Characterization of SN-6, a novel exchange inhibitor and its renal protective effect]
Yutaka Inoue1, Kazuhiko Ito, Takahiro Sakaue
1Laboratory for Discovery Research, Pharmaceutical Research & Development Division, Senju Pharmaceutical Co. Ltd.
Abstract:
Recently, we developed 2-(4- [4-nitrobenzyloxy] benzyl) thiazolidine-4-carboxylic acid ethyl ester (SN-6), a newly synthesized and selective inhibitor of Na(+)/Ca(2+) exchanger. SN-6 is a selective inhibitor for the Ca(2+) influx mode of Na(+)/Ca(2+) exchanger. And this compound attenuated hypoxia/reoxygenation-induced renal tubular cell damage and ischemia/reperfusion-induced renal failure. These results suggest that SN-6 is expected to be pharmacological tools to study the roles of the exchanger and a new anti-ischemic drug.
Related Concept Videos
Renal Drug Excretion: Tubular Secretion
Renal Drug Excretion: Overview
A nephron consists of two primary structures: the renal corpuscle and the renal tubule. The renal corpuscle contains the glomerulus, a network of capillaries where the first step of renal excretion, glomerular filtration, occurs. Blood pressure forces water, ions, and small molecules out...
Renal Drug Excretion: Tubular Reabsorption
Acute Kidney Injury IV: Diagnostic Studies and Prevention
Renal Drug Clearance: Overview
Renal clearance can be calculated using different methods. One approach is to divide the urinary drug excretion rate by the plasma drug concentration. This method directly measures renal clearance, indicating the kidneys' efficiency in...
Renal Failure: Dose Adjustments
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...