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Novel dammarane-type glycosides from Gynostemma pentaphyllum
Feng Yin1, Lihong Hu, Ruixiang Pan
1National Center for Drug Screening, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 189 Guo-Shou-Jing Road, Shanghai 201203, China.
Chemical & Pharmaceutical Bulletin
|December 4, 2004
Summary
Researchers identified three new dammarane glycosides and five known compounds from Gynostemma pentaphyllum. Compounds gylongiposide I, allantoin, and vitexin were newly discovered in this plant.
Area of Science:
- Natural Product Chemistry
- Phytochemistry
- Organic Chemistry
Background:
- Gynostemma pentaphyllum, a medicinal herb, is known for its diverse bioactive compounds.
- Dammarane glycosides are a significant class of compounds found in Gynostemma species.
Purpose of the Study:
- To isolate and characterize novel compounds from the aerial parts of Gynostemma pentaphyllum.
- To identify known compounds present in the plant extract.
Main Methods:
- Extraction of aerial parts of Gynostemma pentaphyllum using methanol.
- Isolation of compounds using chromatographic techniques.
- Structure elucidation using 1D and 2D Nuclear Magnetic Resonance (NMR) spectroscopy and chemical degradation.
Main Results:
- Three new dammarane glycosides (compounds 1-3) were isolated.
- Five known compounds, including gypenoside LXIX (4), gylongiposide I (5), gypenoside XLVIII (6), allantoin (7), and vitexin (8), were identified.
- Compounds 5, 7, and 8 were reported from this plant for the first time.
Conclusions:
- The study successfully identified new and known dammarane glycosides from Gynostemma pentaphyllum.
- The findings contribute to the phytochemical knowledge of Gynostemma pentaphyllum, highlighting the presence of novel glycosides and previously unreported known compounds.