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Updated: Aug 20, 2026

Identifying Dysregulated Genes Induced by Kaposi's Sarcoma-associated Herpesvirus (KSHV)
Published on: September 14, 2010
Immune reconstitution inflammatory syndrome associated with Kaposi sarcoma during potent antiretroviral therapy
Elizabeth Connick1, Madeleine A Kane, Irene E White
1Division of Infectious Diseases, University of Colorado Health Sciences Center, Denver 80262, USA. liz.connick@uchsc.edu
Abstract:
Rapidly progressive Kaposi sarcoma (KS) lesions with lymphadenopathy and tissue swelling occurred in a patient during antiretroviral treatment, despite an increased CD4(+) lymphocyte count and decreased HIV-1 level and KS-associated herpesvirus replication, suggesting immune reconstitution inflammatory syndrome. Inflammation resolved coincident with decreases in the CD4(+) lymphocyte count during paclitaxel treatment, whereas KS cleared only after prolonged antiretroviral therapy and chemotherapy.
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