Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Galectin-1 in regenerating motoneurons.

J McGraw1, L T McPhail, L W Oschipok

  • 1International Collaboration On Repair Discoveries, 6270 University Boulevard, University of British Columbia, Vancouver, Canada, V6T 1Z4.

The European Journal of Neuroscience
|December 8, 2004
PubMed
Summary

Galectin-1 (gal-1) expression increases in facial motoneurons after nerve injury. This protein aids peripheral nerve regeneration and functional recovery in mice.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Polymer-Based CMUT Probe for Imaging the Spinal Cord in Rats.

IEEE transactions on ultrasonics, ferroelectrics, and frequency control·2025
Same author

Fatherhood experiences: A qualitative approach of cisgender and transgender fathers in assisted reproductive technologies (ART) situation with sperm donation.

Heliyon·2024
Same author

Compensatory changes after spinal cord injury in a remyelination deficient mouse model.

Journal of neurochemistry·2024
Same author

Radiography used to measure internal spinal cord deformation in an in vivo rat model.

Journal of biomechanics·2018
Same author

Activity of the antioxidant enzyme paraoxonase in Argentinean children living at high altitude.

Redox report : communications in free radical research·2017
Same author

Routine checking of all manuscripts for plagiarism and duplicate publications.

Spinal cord·2017

Area of Science:

  • Neuroscience
  • Regenerative Medicine
  • Molecular Biology

Background:

  • Recombinant galectin-1 (gal-1) administration enhances peripheral nerve regeneration.
  • Endogenous galectin-1 expression rises in neurons post-axotomy.

Purpose of the Study:

  • To investigate the regulation of endogenous galectin-1 mRNA expression in facial motoneurons following nerve injury.
  • To determine the role of galectin-1 in functional recovery after facial nerve injury.

Main Methods:

  • Quantification of galectin-1 mRNA in mouse facial motoneurons after nerve resection or crush injury.
  • Assessment of galectin-1 expression changes following target re-innervation and axonal transport blockade (colchicine).
  • Evaluation of galectin-1 mRNA levels after glial-derived neurotrophic factor (GDNF) injection.

Related Experiment Videos

  • Functional recovery assessment in galectin-1 null mutant mice after facial nerve crush.

    • Main Results:

    • Nerve injury significantly increased galectin-1 mRNA in facial motoneurons.
    • Loss of target-derived factors and axonal transport blockade contributed to increased galectin-1 expression.
    • GDNF administration also elevated galectin-1 mRNA levels.
    • Galectin-1 null mutant mice exhibited delayed functional recovery of whisking movements.

    Conclusions:

    • Endogenous galectin-1 expression in facial motoneurons is upregulated post-injury, influenced by target-derived signals and potentially positive factors like GDNF.
    • Galectin-1 plays a crucial role in promoting functional recovery following peripheral nerve damage.