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Related Experiment Videos

Drosophila Bys is nuclear and shows dynamic tissue-specific expression during development.

Mary J Stewart1, Erik K Nordquist

  • 1Department of Biological Sciences, North Dakota State University, Fargo, ND 58105, USA. Mary.Stewart@ndsu.nodak.edu

Development Genes and Evolution
|December 8, 2004
PubMed
Summary

The function of the Bys-like gene family is conserved across species. Drosophila Bys protein is found in the nucleus, suggesting a conserved role in ribosome biogenesis, similar to yeast Enp1.

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Area of Science:

  • Developmental Biology
  • Molecular Biology
  • Genetics

Background:

  • The bys-like gene family is evolutionarily conserved from yeast to humans.
  • Human Bystin is implicated in cell adhesion during embryo implantation.
  • Yeast Enp1, a bys-like protein, functions in nuclear pre-ribosomal RNA splicing and ribosome biogenesis.

Purpose of the Study:

  • To investigate the function of the Drosophila melanogaster bys-like gene family member, Bys.
  • To examine the expression patterns of bys mRNA and the cellular localization of Bys protein in Drosophila.

Main Methods:

  • Analysis of bys mRNA expression patterns in Drosophila embryos and larval wing imaginal discs.
  • Determination of Bys protein localization in Schneider line 2 (S2) cells using epitope tagging.

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Main Results:

  • Bys mRNA exhibits tissue-specific expression during embryonic gastrulation and in specific regions of the larval wing imaginal disc.
  • Expression patterns suggest potential roles in cell-cell interactions and processes regulated by Myc.
  • Drosophila Bys protein localizes to the nucleus in S2 cells.

Conclusions:

  • Drosophila Bys mRNA expression patterns are consistent with roles in cell adhesion and potentially cell growth.
  • Nuclear localization of Bys protein suggests conserved function with yeast Enp1 in ribosome biogenesis.