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Updated: Aug 20, 2026

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Co-occurrence of Wilson's disease and glioblastoma multiforme--is it a chance association?
S Sinha1, L K Prashanth, A Mahadevan
1Department of Neurology, National Institute of Mental Health and Neurosciences, Bangalore, India.
Abstract:
We report a patient with glioblastoma multiforme who was subsequently diagnosed to have Wilson's disease. Immunohistochemical studies of the tumor revealed high (> 60%) labeling index for p53 and Rb retinoblastoma protein. Whether this association is like the co-occurrence of retinoblastoma and Wilson's disease due to possible somatic mutation in chromosome 13 needs to be explored.
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