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Related Experiment Videos

SIADH consecutive to ciprofloxacin intake.

Dan Adler1, Cathy Voide, Jean-Benoît Thorens

  • 1Internal Medicine Department, University Hospital of Geneva, Rue Micheli-du-Crest 24, 1211 Geneva 14, Switzerland.

European Journal of Internal Medicine
|December 8, 2004
PubMed
Summary

Ciprofloxacin can cause Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH), leading to severe hyponatremia and seizures. This drug should be considered a potential cause of SIADH in clinical practice.

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Area of Science:

  • Endocrinology
  • Pharmacology
  • Nephrology

Background:

  • Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH) is frequently associated with drug administration.
  • Identifying novel drug-induced SIADH cases is crucial for patient safety and clinical management.

Purpose of the Study:

  • To report the first documented case of SIADH induced by ciprofloxacin.
  • To highlight the potential of ciprofloxacin to cause severe hyponatremia.

Main Methods:

  • Case report of a 70-year-old patient with a history of post-actinic bladder and hematuria.
  • Observation of SIADH development after ciprofloxacin administration on two separate occasions.
  • Exclusion of other potential causes of SIADH and assessment of drug rechallenge.

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Main Results:

  • The patient experienced severe hyponatremia and seizures following ciprofloxacin administration.
  • Symptoms resolved rapidly upon discontinuation of ciprofloxacin.
  • Positive drug rechallenge confirmed ciprofloxacin as the causative agent.

Conclusions:

  • Ciprofloxacin is a potential iatrogenic cause of SIADH.
  • Clinicians should consider ciprofloxacin when evaluating drug-induced SIADH.
  • Further investigation into ciprofloxacin's role in SIADH is warranted.