Related Experiment Video
Updated: Aug 20, 2026
Studying Chronic Exposure of Mice to Ultraviolet B Radiation
Published on: August 19, 2025
Chronic stress accelerates ultraviolet-induced cutaneous carcinogenesis
Jason Parker1, Sabra L Klein, Martha K McClintock
1Department of Dermatology, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA.
Background:
Physical and emotional stressors have been found to mediate a wide variety of biological changes including the facilitation of tumor progression; however most of these paradigms utilized artificial sources of neoplasms and stress.
Methods:
Skh mice were exposed to carcinogenic doses of ultraviolet light (UV). The stressed group was subjected to the close proximity of fox urine as a source of stress from the presence of the odor of their natural predator, while the control group remained stress free.
Results:
A significant acceleration in the development of cutaneous neoplasms was observed in mice that had been exposed to the stressor. The first tumor appeared in the group after 8 weeks, whereas nonstressed mice began to develop these by week 21.
Conclusion:
These results suggest that stress plays a role in potentiating cutaneous carcinogenesis.
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