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Generation of Immature, Mature and Tolerogenic Dendritic Cells with Differing Metabolic Phenotypes
Published on: June 22, 2016
Generation of clinical-grade monocyte-derived dendritic cells using the CliniMACS system
Thomas Putz1, Hubert Gander, Reinhold Ramoner
1Department of Urology, University of Innsbruck, Innsbruck, Austria.
Methods in Molecular Medicine
|December 9, 2004
Abstract:
We describe the generation of monocyte-derived dendritic cells (MoDC) from leukapheresis products using the CliniMACS system from Miltenyi Biotec. In a clinical setting, the method turned out to be feasible for the generation of clinical-grade MoDC from patients with metastatic renal-cell carcinoma. MoDC generated with this system exhibited a fully mature phenotype as well as high migratory and T-cell stimulatory capacity.
