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Updated: Aug 20, 2026

Multimodality Diagnosis of Mesenteric Ischemia
Published on: July 21, 2023
Mitral valve prolapse associated with celiac artery stenosis: a new ultrasonographic syndrome?
1Guglielmo Marconi University - ASDAC (Updating and Teaching in Cardiology, Scientific Association), ARCA Lazio, Rome, Italy. luciano.arcari@fastwebnet.it
Insights
Celiac artery stenosis (CAS) and mitral valve prolapse (MVP) are significantly associated. This study found a 39% agreement between these conditions in patients undergoing screening.
Area of Science:
- Cardiology
- Vascular Medicine
- Diagnostic Imaging
Background:
- Celiac artery stenosis (CAS) can result from atherosclerosis or diaphragm compression.
- Mitral valve prolapse (MVP) is a common valvular heart condition.
- No prior reports have documented an association between CAS and MVP.
Purpose of the Study:
- To investigate the potential association between celiac artery stenosis (CAS) and mitral valve prolapse (MVP).
- To determine the prevalence of CAS in patients undergoing echocardiography for MVP.
- To identify predictors of CAS in patients with MVP.
Main Methods:
- Doppler sonography of the celiac tract was performed on 1560 patients assessed for MVP.
- A total of 3780 consecutive patients were included in the screening.
- Multivariate logistic regression was used to identify predictors of CAS.
Main Results:
- Celiac artery stenosis (CAS) was detected in 3.7% of subjects.
- Mitral valve prolapse (MVP) was observed in 82.4% of subjects with CAS and 7.9% without CAS (p < 0.001).
- Peak systolic velocity (PSV) was the sole predictor of CAS in MVP patients (OR 0.24).
Conclusions:
- Celiac artery stenosis (CAS) and mitral valve prolapse (MVP) demonstrate a significant association.
- These findings suggest a link between valvular and vascular conditions.
- Ultrasonographic screening may reveal concurrent CAS and MVP.
Background:
Celiac artery stenosis (CAS) may be caused by atherosclerotic degeneration or compression exerted by the arched ligament of the diaphragm. Mitral valve prolapse (MVP) is the most common valvular disorder. There are no reports on an association between CAS and MVP.
Methods:
1560 (41%) out of 3780 consecutive patients undergoing echocardiographic assessment of MVP, had Doppler sonography of the celiac tract to detect CAS.
Results:
CAS was found in 57 (3.7%) subjects (23 males and 34 females) none of whom complained of symptoms related to visceral ischemia. MVP was observed in 47 (82.4%) subjects with and 118 (7.9%) without CAS (p < 0.001). The agreement between MVP and CAS was 39% (95% CI 32-49%). PSV (Peak Systolic Velocity) was the only predictor of CAS in MPV patients (OR 0.24, 95% CI 0.08-0.69) as selected in a multivariate logistic model.
Conclusion:
CAS and MVP seem to be significantly associated in patients undergoing consecutive ultrasonographic screening.
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