Related Experiment Videos
From circumscribed scleroderma (morphea) to subcutaneous panniculitis-like T-cell lymphoma: case report
Nina Troskot1, Liborija Lugović, Mirna Situm
1Department of Dermatology and Venerology, Sestre milosrdnice University Hospital, Vinogradska c. 29, 10000 Zagreb, Croatia.
Acta Dermatovenerologica Croatica : ADC
|December 14, 2004
Summary
Subcutaneous panniculitis-like T-cell lymphoma, a rare non-Hodgkin lymphoma, can mimic morphea. Repeat biopsies and immunohistochemistry are crucial for accurate diagnosis of this skin lymphoma.
Area of Science:
- Oncology
- Dermatology
- Pathology
Background:
- Subcutaneous panniculitis-like T-cell lymphoma (SPTCL) is a rare non-Hodgkin lymphoma.
- It clinically presents as panniculitis with subcutaneous infiltrates and nodules.
Observation:
- A 45-year-old male presented with tender subcutaneous skin lesions initially diagnosed as morphea.
- Subsequent biopsies revealed SPTCL, characterized by atypical CD8(+) T-lymphoid cells and phagocytic histiocytes.
Findings:
- Initial biopsies suggested morphea, but later analysis confirmed SPTCL.
- Immunohistochemistry identified a dense infiltrate of atypical CD8(+) T-lymphoid cells in subcutaneous tissue.
Implications:
- This case highlights the diagnostic challenges of SPTCL, especially when co-occurring with morphea.
- Emphasizes the importance of repeat biopsies and advanced techniques like immunohistochemistry for early and accurate diagnosis of rare lymphomas.