Three-dimensional ultrasound measurement of thyroid volume in asymptomatic male Chinese

This study was undertaken to determine the accuracy and reliability of volume measurements using 3-D ultrasound (US). Variation of thyroid gland volume with age in asymptomatic Chinese men was also investigated. Volumetric measurements of the phantoms and thyroid glands were performed with a commercially available US machine in conjunction with the 3-D SonoScan Pro workstation. Ten tissue phantoms with volumes of 1.5 to 6.5 mL were measured with 3-D US. A water displacement method was used to measure the actual volume of the phantoms. The measured volumes were compared to the actual volumes. Volumes were measured by four operators to investigate interobserver variation. Thyroid US examinations were performed in 38 asymptomatic male Chinese subjects ages 21 to 72 years. The subjects were categorized into four age groups. In each subject, the volume of the left and right lobes and the isthmus of the thyroid gland were measured with 3-D US, and any variation with age was evaluated. Results showed that the actual volume of the tissue phantoms was highly correlated with the volume measured by the four operators (r = 0.9912 to 0.9977, p < 0.05). Interobserver variation in the volumetric measurements of the tissue phantoms was not significant (ICC = 0.9861). The range of thyroid volume of the subjects was 8.81 to 17.25 mL (mean 12.78 +/- SD 2.483), and there was no significant difference in thyroid volume between subjects of different age groups (p > 0.05). 3-D US is an accurate and reliable method by which to measure thyroid volume.