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Large cell variant of small cell carcinoma, hypercalcemic type, of primary peritoneal origin
Dorota A Popiolek1, Asok R Kumar, Khush Mittal
1Department of Pathology, 4W35B, New York University School of Medicine, Belluvue Hospital, 462 First Avenue, New York, NY 10016, USA. dorota.popiolek@med.nyu.edu
Background:
Large cell variant of small cell carcinoma hypercalcemic type (SCC-HT) is extremely rare. All reported cases involved an ovary, and one with primary peritoneal origin has not been described. Also, convincing neuroendocrine granules have not been illustrated.
Case:
A 35-year-old woman underwent an exploratory laparotomy for leiomyomas. Intraoperative impression of peritoneal carcinomatosis was confirmed on frozen section. TAH/BSO, debulking/omentectomy followed. The tumor was present on the pelvic/abdominal peritoneum. The normal-sized ovaries were free of tumor grossly. The tumor had features of large cell variant of SCC-HT, described in the ovary. Furthermore, unequivocal neuroendocrine granules were present. The patient received standard chemotherapy for SCC. At 22 months she is NED.
Conclusion:
SCC-HT should be considered in the differential diagnosis of primary neoplasms of the peritoneum.
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