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CA-125 serum levels and pregnancy outcome in in vitro fertilization

Karen E Fish1, Maureen Phipps, James Trimarchi

  • 1Department of Obstetrics and Gynecology, Women & Infant's Hospital of Rhode Island, Providence, Rhode Island 02905, USA.

Fertility and Sterility
|December 14, 2004
PubMed

This is a prospective cohort study of CA-125 levels drawn on the day of hCG administration in 386 women undergoing IVF treatment. The CA-125 levels were not helpful in determining pregnancy outcome, as indicated by poor sensitivity (40.8%) and specificity (52.7%), as well as an area under the receiver operator characteristic curve close to 0.50.

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In vitro fertilization (IVF) is a form of assisted reproductive technology where an egg is fertilized with sperm in a controlled laboratory environment before transferring the resulting embryo into the uterus. This process is designed to help individuals and couples experiencing difficulties conceiving.
The IVF process begins with ovarian stimulation, during which reproductive endocrinologists prescribe hormonal medications to stimulate the ovaries to produce multiple eggs instead of the single...