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Updated: Aug 20, 2026

Pulsed Wave Doppler Assessment of Diastolic Dysfunction in the ZSF-1 Rat Model of Pulmonary Hypertension Due to Left Heart Disease
Published on: May 22, 2026
[Short-term effect of nebivolol on the left ventricular diastolic function]
Ergün Demiralp1, Ejder Kardeşoğlu, Turgay Celik
1Department of Cardiology, Haydarpaşa Education Hospital, Gülhane Military Medical Academy, Istanbul.
Objective:
To determine the effects of nebivolol on diastolic functions of the left ventricle in the hypertensive patients in the early treatment period.
Methods:
Twenty patients with mild to moderate hypertension taking daily 5 mg of nebivolol were assessed by using Doppler echocardiography before and after 6-week drug treatment period. The results were analyzed with Wilcoxon test and p<0.05 was accepted as statistically significant value.
Results:
The arterial blood pressure and heart rate of the patients significantly decreased after 6 weeks of treatment. Statistically significant decrease was found in the peak of A wave velocity, isovolumetric relaxation time, E wave deceleration time and increase in E/A ratio with Doppler echocardiography after 6-week treatment period. No statistically significant difference was observed in the peak velocity of E wave after treatment period.
Conclusion:
We found that nebivolol improved left ventricular diastolic function in patients with hypertension in the early term.
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