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Polymorphisms in the CD14 gene associated with pulmonary function in farmers
Tricia D LeVan1, Susanna Von Essen, Debra J Romberger
1Arizona Respiratory Center and Departments of Internal Medicine and Pediatrics, College of Medicine, University of Arizona, Tucson, Arizona, USA.
American Journal of Respiratory and Critical Care Medicine
|December 14, 2004
Summary
Certain CD14 gene variants are linked to reduced lung function and increased wheezing in farmers exposed to endotoxins. These findings suggest a role for CD14 in respiratory health in agricultural workers.
Area of Science:
- Environmental Health
- Immunogenetics
- Pulmonary Medicine
Background:
- Farmers face occupational airway obstruction, potentially due to endotoxin inhalation.
- CD14 acts as a receptor for endotoxins, playing a role in the immune response.
Purpose of the Study:
- To investigate the association between CD14 gene polymorphisms and lung function in farmers.
- To determine if specific CD14 alleles influence endotoxin-related respiratory symptoms.
Main Methods:
- Genotyping of CD14/-159, CD14/-1619, and TLR4/Asp299Gly loci in farmers.
- Assessment of lung function using FEV1 and FEF25-75.
- Analysis of wheezing prevalence in relation to genotypes.
Main Results:
- Farmers with CD14/-159TT genotype showed significantly lower FEV1 and FEF25-75.
- CD14/-1619GG genotype was also associated with reduced lung function (FEV1, FEF25-75).
- Increased wheezing prevalence was observed in farmers with CD14/-159T or CD14/-1619G homozygous genotypes.
Conclusions:
- CD14/-159 and CD14/-1619 genetic variations may influence lung function in agricultural workers.
- These CD14 loci appear to modulate respiratory health, including wheeze, in endotoxin-exposed individuals.
