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Thrombotic microangiopathy with liver, gut, and bone infarction (catastrophic antiphospholipid syndrome) associated

Martial Koenig1, Michel Roy, Sylviane Baccot

  • 1Department of Internal Medicine, Hôpital Nord, CHU Saint-Etienne, 42055 Saint-Etienne Cedex 2, France. martial.koenig@chu-st-etienne.fr

Clinical Rheumatology
|December 14, 2004
PubMed

Hemolysis, elevated liver enzymes, low platelet count (HELLP) syndrome is a thrombotic microangiopathy complicating pregnancy and shares many clinical and biological features with thrombotic thrombocytopenic purpura (TTP) and hemolytic uremic syndrome (HUS). Thrombotic microangiopathy is also a pathological feature of catastrophic antiphospholipid syndrome (CAPS). An association between refractory HELLP syndrome and antiphospholipid syndrome (APS) has been reported in a few cases. We describe a 19-year-old woman with APS and multiorgan failure conforming to a diagnosis of CAPS who developed refractory HELLP syndrome.

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