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Unusually high occurrence of drug reactions with nafcillin
The Yale Journal of Biology and Medicine
|July 1, 1978
Abstract:
Five patients seen during a two-month period who developed untoward systemic reactions following high dose intravenous administration of nafcillin are described. Recovery was complete upon discontinuation of the drug. The clustering of these cases and the high incidence (5 of 5) of side effects are highly unusual, and suggest that the frequency of nafcillin reactions might be higher than previously suspected.
Insights
High doses of nafcillin intravenously can cause severe systemic reactions in patients. Promptly stopping the drug led to complete recovery, suggesting a higher reaction frequency than previously thought.
Area of Science:
- Pharmacology
- Clinical Medicine
- Adverse Drug Reactions
Background:
- Nafcillin is an antibiotic commonly used for bacterial infections.
- High-dose intravenous administration is a recognized route of therapy.
- Systemic reactions to nafcillin are considered rare.