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Related Experiment Videos

Decrease in haematocrit with continuous positive airway pressure treatment in obstructive sleep apnoea patients.

J Krieger1, E Sforza, C Delanoe

  • 1Sleep Disorders Unit, University Hospital, Strasbourg, France.

The European Respiratory Journal
|February 1, 1992
PubMed
Summary
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Continuous positive airway pressure (CPAP) treatment for obstructive sleep apnoea (OSA) significantly decreases haematocrit and red cell count. These changes reverse with treatment cessation and reappear upon restarting CPAP therapy.

Area of Science:

  • Hematology
  • Sleep Medicine
  • Respiratory Physiology

Background:

  • Previous studies indicated a potential decrease in hematocrit and red cell count after the initial night of CPAP treatment for OSA.
  • The physiological mechanisms underlying these preliminary findings required further investigation and long-term analysis.

Purpose of the Study:

  • To confirm preliminary findings on overnight changes in hematocrit and red cell count with CPAP in OSA patients.
  • To investigate the long-term effects of CPAP therapy on these hematological parameters.
  • To explore potential correlations between hematological changes and fluid balance alterations during CPAP treatment.

Main Methods:

  • Prospective study measuring hematocrit and red cell count in 80 OSA patients over two consecutive nights (untreated vs. CPAP).

Related Experiment Videos

  • Analysis of hematological parameters after a period of CPAP cessation and reinitiation.
  • Long-term follow-up (≥1 year) in 21 patients evaluating hematocrit and red cell count after CPAP and untreated nights.

    • Main Results:

    • CPAP treatment significantly decreased both hematocrit (44.0% to 42.4%) and red cell count (4.769 x 10^12/L to 4.597 x 10^12/L).
    • These hematological decreases were not correlated with changes in urine volume or flow.
    • Hematocrit and red cell count returned to baseline levels after CPAP cessation and decreased again upon resuming treatment; long-term CPAP use showed slightly higher, but still reduced, levels compared to baseline untreated nights.

    Conclusions:

    • CPAP therapy in OSA patients leads to a significant, reversible decrease in hematocrit and red cell count.
    • The observed hematological changes are independent of fluid shifts related to urine output.
    • Long-term CPAP use maintains hematological parameters at levels lower than baseline, suggesting a sustained effect beyond the initial treatment nights.