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Related Experiment Videos

Corporal veno-occlusive dysfunction in aging rats: evaluation by cavernosometry and cavernosography.

H H Davila1, J Rajfer, N F Gonzalez-Cadavid

  • 1Harbor-University of California, Los Angeles, Research and Education Institute, Torrance, California 90502, USA.

Urology
|December 15, 2004
PubMed
Summary

Aging causes corporal veno-occlusive dysfunction (CVOD) in rats, primarily through the deep dorsal vein (DDV). Aged rats serve as a valid model for studying erectile dysfunction linked to CVOD.

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Area of Science:

  • Urology
  • Andrology
  • Aging Research

Background:

  • Erectile dysfunction (ED) is a common concern in aging populations.
  • Corporal veno-occlusive dysfunction (CVOD) is a significant cause of ED.
  • The aging process's impact on CVOD requires further investigation in animal models.

Purpose of the Study:

  • To investigate the development of CVOD in aging male Fisher 344 rats.
  • To establish the aged rat as a suitable model for studying age-related ED and CVOD.

Main Methods:

  • Male Fisher 344 rats were divided into young intact, young castrated, aged intact, and aged deep dorsal vein (DDV) ligated groups.
  • Measurements included serum testosterone, dynamic infusion cavernosometry, and cavernosography.
  • Dual-energy x-ray absorptiometry scans were utilized for cavernosography.

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Main Results:

  • Aged intact rats exhibited significantly reduced testosterone levels and intracavernosal pressure compared to young intact rats.
  • Dynamic infusion cavernosometry revealed increased venous leakage in aged rats, comparable to young castrated controls.
  • Cavernosography identified the DDV as the primary site of venous leakage in aged rats.

Conclusions:

  • The aged rat model demonstrates CVOD, predominantly via the DDV.
  • This study supports the aged rat as an appropriate model for researching ED associated with CVOD.