[Grave's disease in children with 22q11 deletion. Report of three cases]
J Gosselin1, B Lebon-Labich, H Lucron
1Service de médecine infantile III et de génétique clinique, hôpital d'enfants, rue du Morvan, 54511 Vandoeuvre, France.
Abstract:
Hypothyroidism is a well recognized complication of 22q11.2 deletion syndrome. Auto-immune hyperthyroidism is less common. We report three patients with a 22q11.2 deletion and Graves' disease diagnosed at age 17, 14 and 11 years, respectively. The clinical and biological presentation was typical for auto-immune hyperthyroidism. Graves' disease should be periodically sought during the follow-up program of patients with 22q11.2 deletion syndrome.
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