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[Polymorphisms related to SIRS and inflammatory response].
Toshihiko Mayumi1, Takuro Arishima, Hideo Takahashi
1Department of Emergency Medicine and Intensive Care, Nagoya University School of Medicine.
Nihon Rinsho. Japanese Journal of Clinical Medicine
|December 16, 2004
Summary
Gene polymorphisms influence disease susceptibility and outcomes, impacting inflammatory response and infection severity. Understanding these genetic variations can personalize prevention and treatment strategies for infectious diseases.
Area of Science:
- Genetics and Molecular Biology
- Immunology
- Infectious Diseases
Context:
- Susceptibility and outcomes of diseases are increasingly linked to specific gene polymorphisms.
- Systemic Inflammatory Response Syndrome (SIRS) and general inflammation are complex processes influenced by genetic factors.
- Numerous polymorphisms in genes like TNF, IL-1, PAI-1, and TLR have been investigated for their association with infections.
Purpose:
- To review the role of gene polymorphisms in systemic inflammatory response syndrome (SIRS) and inflammation.
- To explore the contribution of genetic variations to disease susceptibility and patient outcomes in infectious diseases.
- To highlight the clinical utility of gene polymorphism information for personalized medicine.
Summary:
- Gene polymorphisms, particularly in cytokine genes, can elevate cytokine expression and production, correlating with increased prevalence, morbidity, and mortality in infections.
- Analysis of individual gene polymorphisms offers valuable insights for preventing and treating infectious diseases.
- This information aids in identifying patients requiring intensive therapy and tailoring treatment on a case-by-case basis.
Impact:
- Genetic profiling can guide personalized prevention and therapeutic strategies for infectious diseases.
- Identifying specific gene polymorphisms allows for targeted interventions and improved patient management.
- Further multi-center studies, especially in diverse populations like the Japanese, are needed to fully elucidate the impact of gene polymorphisms on disease outcomes.