[Epithelial and stromal cell relation in peritumorous zone of the prostate gland cancer]

This article deals with an urgent topic--assessment of peculiar characteistics of epithelial-stromal interactions in prostate gland tissues outside the tumor growth zone. On demonstrating pre-cancerous changes, this zone can either further accompany or precede the development of malignant neoplasm. The authors have established suppression of general morpho-functional activity of histogematogenous barrier components, increase in degenerative changes in epithelium, both in the vicinity of the tumor, and at a distance from it, which is, most probably, caused by dishormonal changes. We demonstrated the growth of lymphocytic-monocytic infiltration, and a decreased number of fibroblasts and endothelial cells of prostate gland tissues outside the tumor growth zone. The discovered changes of the histogematogenous barrier condition in the peritumorous zone and the benign hyperplasia can serve an additional criterion for early diagnostics of pre-cancerous changes of the prostate gland.