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TAT conjugated, FITC doped silica nanoparticles for bioimaging applications
Swadeshmukul Santra1, Heesun Yang, Debamitra Dutta
1Department of Neurological Surgery, University of Florida, PO Box 100265, Gainesville, FL 32610, USA. santra@neurosurgery.ufl.edu
Chemical Communications (Cambridge, England)
|December 16, 2004
Abstract:
Water-in-oil (w/o) microemulsion synthesis of 70 nm size monodisperse TAT (a cell penetrating peptide, CPP) conjugated, FITC (fluorescein isothiocyanate) doped silica nanoparticles (TAT-FSNPs) is reported; human lung adenocarcinoma (A549) cells (in vitro) and rat brain tissue (in vivo) were successfully labeled using TAT-FSNPs.
